Dementia Memory

(© pathdoc - stock.adobe.com)

HOUSTON, Texas — Anti-aging treatments are a popular field of study these days, as more and more people are living into their 70s and 80s. However, a new study reveals the answer to preventing cognitive decline as we age may have been sitting in our blood all along. Researchers have discovered a protein in red blood cells which has the power to prevent memory loss and other age-related issues in the brain.

Tests in mice find that removing the protein adenosine receptor A2B (ADORA2B) from red blood cells triggers faster declines in memory, the ability to recognize sounds, and leads to higher levels of inflammation in the brain.

ADORA2B helps deliver oxygen to keep us young

It’s no secret that as the human body ages, people begin to slow down. With more people reaching old age in modern times, more people are developing age-related diseases like dementia. Study authors explain that the amount of oxygen in the blood also declines as people age.

They add that ADORA2B, a protein on the membrane of red blood cells, helps to release oxygen so the rest of the body can use it. With that in mind, an international team set out to see how large of a role ADORA2B plays in keeping the brain youthful and active.

Researchers engineered a group of mice which lack ADORA2B in their blood. They compared these animals to normal mice, examining their mental decline as they got older. Results reveal all of the typical signs of cognitive decline — poor memory, hearing problems, and brain inflammation — were worse in mice lacking ADORA2B protein.

Moreover, after experiencing a lack of oxygen throughout their bodies, study authors discovered that behavioral and physiological trauma to mice without the anti-aging protein was more severe than in normal mice. Due to these findings, scientists conclude that ADORA2B slows the natural aging of the brain by delivering oxygen vital to its normal functioning.

“Red blood cells have an irreplaceable function to deliver oxygen to maintain bioenergetics of every single cell within our body. However, their function in age-related cognition and hearing function remains largely unknown. Our findings reveal that the red blood cell ADORA2B signaling cascade combats early onset of age-related decline in cognition, memory and hearing by promoting oxygen delivery in mice and immediately highlight multiple new rejuvenating targets,” says study author Dr. Yang Xia from the University of Texas McGovern Medical School in a media release.

The team published their findings in the journal PLOS Biology.

About Chris Melore

Chris Melore has been a writer, researcher, editor, and producer in the New York-area since 2006. He won a local Emmy award for his work in sports television in 2011.

Our Editorial Process

StudyFinds publishes digestible, agenda-free, transparent research summaries that are intended to inform the reader as well as stir civil, educated debate. We do not agree nor disagree with any of the studies we post, rather, we encourage our readers to debate the veracity of the findings themselves. All articles published on StudyFinds are vetted by our editors prior to publication and include links back to the source or corresponding journal article, if possible.

Our Editorial Team

Steve Fink

Editor-in-Chief

Chris Melore

Editor

Sophia Naughton

Associate Editor