The 5 Most Effective Headache Medicines Across Expert Reviews

Picture this: You’re living your best life when suddenly, a headache hits like a surprise guest at a party who brought nothing but bad vibes. Before you start daydreaming about a brain transplant, let’s talk headache medicine. Whether it’s a nagging tension headache from staring at screens or a full-blown migraine that makes you question your existence, we’ve got the lowdown on the best remedies. Get ready to kiss those head-throbbers goodbye and say hello to sweet, sweet relief! When you want to get rid of a headache, here’s what 11 doctors, pharmacists, and medical professionals recommend as the best headache medicine on the market. Our list is comprised of the most frequently named pain relievers across these reviews. If you have your own suggestions or opinions, please leave them in the comments below!

1. Advil (Ibuprofen)

Advil has been studied for years. MedicalNewsToday explains, “A 2015 research study examined the benefits of ibuprofen in people with frequent tension-type headaches. The researchers concluded that those with acute headaches with moderate or severe initial pain who took ibuprofen had up to 2 hours of relief. Additionally, ibuprofen also helps with inflammation symptoms such as arthritis and joint pain.” 

In a Tylenol vs. Advil battle, Verywell Health says, “Ibuprofen works better: In an older study published in the Journal of Clinical Pharmacology, over 450 individuals with tension headache received either 400 milligrams (mg) ibuprofen, 1,000 mg of acetaminophen, or a placebo (an inactive sugar pill). Results showed both medications were more effective than placebo in alleviating headache, with ibuprofen the most effective.” 

UC San Diego Health writes, “NSAIDS — or nonsteroidal anti-inflammatory drugs — are the first line of treatment when it comes to migraines. These include Advil.” 

2. Aleve (Naproxen)

University of Michigan Health asked a neurologist for her pick for headache relief: “Neurologist and headache specialist Lauren A. Aymen, D.O., explains the best over-the-counter drugs: Nonsteroidal anti-inflammatory medications (NSAIDs) are more powerful compared to acetaminophen because NSAIDs reduce inflammation. Examples of NSAIDs include Motrin, Aleve or Advil. I tend to prefer Aleve (Naproxen).” 

According to GoodRx Health, 78 percent of users say Aleve is worth taking, and here’s why: “Naproxen lasts longer than ibuprofen. The half-life — or time it takes for a medication to lower to half of its starting dose in the body — is about 2 hours for ibuprofen and 12 to 17 hours for naproxen. This is why naproxen does not have to be taken as often as ibuprofen. Similar to ibuprofen, naproxen starts working in as little as 30 minutes. And the side effects are similar as well.” 

3. Excedrin Migraine

U.S. Pharmacist explains why Excedrin Migraine is their first line of defense against migraine headaches: “The first OTC product to gain FDA approval for the treatment of migraine was the combination of acetaminophen, aspirin, and caffeine (AAC), which is available as Excedrin Migraine. The combination of these agents has been shown to be more effective than any one of the components alone in comparable doses. In a landmark study comparing AAC to placebo, 59% of the AAC-treated patients experienced adequate pain relief in 2 hours compared with 33% with placebo. A further analysis of 172 of these patients who had severe or incapacitating disability showed that 40% of the AAC users had mild or no pain at 2 hours versus 20% for placebo.” 

Intense pain requires a medicine that can provide intense relief. “Migraines are not your ordinary headache. As any sufferer can tell you, the pain is severe and is often accompanied by vomiting, vision problems and disorientation. While some people opt for prescription medications, over-the-counter products can help ease migraine pain,” U.S. News writes. And according to their poll, Excedrin Migraine wins the most votes from pharmacists.  

4. Tylenol (Acetaminophen)

Avera recommends Tylenol as a go-to pain relief for headaches, writing, “Starting with acetaminophen, or Tylenol, makes sense for a number of reasons. Acetaminophen has less impact on your kidneys when your body processes it. Acetaminophen is easier on the stomach in most cases. Allergies to acetaminophen are rarer than NSAID allergies. Acetaminophen does not thin our blood. When you take other OTC or prescription drugs, there’s less likelihood of a bad interaction with acetaminophen.”

Cedars-Sinai agrees, saying, “Acetaminophen is another type of pain reliever that works best on headaches, minor aches and pains, and fevers. Unlike NSAIDs, acetaminophen won’t cause stomach issues but can still be harmful if overused. For a mild headache, acetaminophen … can be effective.”

5. Bayer (Aspirin)

This long-established pain reliever is definitely capable of handling a headache. “Although the over-the-counter drug is more than 100 years old, two standard, 325 milligram aspirin pills resolve most headaches in an hour or less. Even some people with migraine find relief with this medication, first developed by the pharmaceutical giant Bayer,” Everyday Health writes.

And according to K Health, “Aspirin can be an effective pain medication for many conditions including migraines. It is considered a first-line migraine treatment … It works by blocking enzymes that make prostaglandins, which can trigger pain and inflammation responses with migraines and other problems.” 

Make sure to see your doctor if your headache persists. We hope you find some pain relief in the options above! 

Sources used to find these top picks

• MedicalNewsToday
• Verywell Health
• UC San Diego Health
• University of Michigan Health
• GoodRx Health
• U.S. News
• U.S. Pharmacist
• Avera
• Cedars-Sinai
• K Health
• Everyday Health

Note: This article was not paid for nor sponsored. StudyFinds is not connected to nor partnered with any of the brands mentioned and receives no compensation for its recommendations. This article may contain affiliate links in which we receive a commission if you make a purchase.