First patient receives potentially cancer-stopping pill in new clinical trial

LOS ANGELES — Researchers at City of Hope, one of the largest integrated cancer research and care centers, say the first patient has received a new cancer-stopping pill and is healthy and well.

The pill, AOH1996, was named after young cancer victim Anna Olivia Healey, who was born in 1996. For 20 years now, Linda Malkas, Ph.D., professor in City of Hope’s Department of Molecular Diagnostics & Experimental Therapeutics, has dedicated her research and development efforts to AOH1996.

In trials, the pill has been effective at targeting the proliferating cell nuclear antigen (PCNA), which has a crucial role in cell repair and replications. Using mutated cells as a target in this way has not only been shown to halt growth of cancerous human cells and inhibit spread, but its mechanism of action doesn’t confer any toxic effects to normal, healthy cells.

“Imagine cancer as the water filling up a bathtub. Left unchecked, the tumors or water will eventually overflow and damage other parts of your home. The treatment my team at City of Hope created is akin to a watchful homeowner who shuts the water off — stopping the spread of tumors to other parts of the metaphorical house — and then drains the tub, eliminating the cancer,” says Malkas, co-investigator in the trial and the M.T. & B.A. Ahmadinia Professor in Molecular Oncology, in a media release.

What types of cancer can the pill treat?

The first patient to receive the drug is part of City of Hope’s Phase 1 Clinical trial. The goal of this trial is to accurately determine the highest tolerable dose of the pill and to study the efficacy in preliminary stages. Patients eligible for participation are adults with solid tumors who haven’t responded well to standard cancer treatments. The research team instructs patients to take the pill twice per day.

“Since many patients’ cancers become resistant to our standard therapies, we need new therapeutics with new mechanisms of action — for example, non-cross resistant. AOH1996 is just that kind of new therapy,” explains Daniel Von Hoff, M.D., of the Molecular Medicine Division at the Translational Genomics Research Institute, part of City of Hope, and an advisor on the study.

So far, the drug has been promising against breast, prostate, ovarian, skin, and lung cancers. Malkas hopes to see the day when AOH1996 becomes an FDA-approved inhibitor drug that can be combined with other therapies like chemotherapy to boost their benefits while not increasing risk of side-effects.

Additionally, she mentions that there are other targeted therapies out there that have helped several cancer patients through hindering cell growth and metastasis. This only reinforces her confidence that AOH1996 can do the same. For now, Malkas hopes to have the Phase 1 trial last over the next two years and carefully evaluate new findings over this time.

The current findings of the clinical trial are available here.

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    1. How about little pharma? Are little-pharma drugs ok? And where is the cut line where little pharma is no longer little?

      1. Well put. I trusted the supposed worlds greatest mind clinic at cleveland clinic and watched my mother bleed to death of a stroke under their care and advice of treatment. Of course they were experimenting. We are all Guinea pigs to them. I have 2 artificial hips as a side effect of prednisone taken for a bad case of poison ivy. Common side affect is avascular necr6of the femoral heads. I had no recourse. The medical system is following the criminal activity of tony Fauci.

    2. Those “not taking anything big pharma is handing out” are free to refuse, while the rest of us are free to happily live long and prosper, be fruitful and multiply, as we fill the vacuum left by their preventable and premature passing from this world.

      Charles Darwin’s survival of the fittest still works well today, silencing the medicine refusers one by one with an early grave.

  1. So then dont bother going to a doctor or hospital with an illness. Ever. Have a heart attack or stroke, just stay home, safe from “big pharma”. I’m sure the problem will just work itself out naturally in the end.

    1. As natural as spikes in miscarriages, myocarditis, and previously dormant cancers … right Bob? Blind faith in a capitalist medical system is as dangerous as petting buffalo in Yosemite.

  2. I strongly suggest you all search Youtube for this title, “How Joe Tippens Beat Terminal Cancer with $7 Dog Medicine Part 1 – Interviewed by James Templeton.”

    The drug is fenbendazole. Diagnosed with terminal lung cancer, Joe was told he had about 3 months to live. A veterinarian friend of his in western Oklahoma called him and told him about a cancer research experiment he had learned about, in which a dog-deworming medicine had cured cancer in the experimental mice… and when the researcher herself developed cancer, she used the same medicine on herself and her glioblastoma was gone in about 12 weeks.

    Joe has a blog- mycancerstoryrocks . com. He has a private Facebook group because of the multitude of emails asking for help. The password for the Facebook group is a the bottom of the blog.

    Fenbendazole works on all cancer tumors. It destroys the wall of the tumor cell, so the cancer can not take in nutrition.

  3. I was diagnosed with Stage 3, Grade A breast cancer at 59yrs old. I had a DMX, 6 months of chemo and 5 weeks of radiation. I stopped at the traditional hormone blockers (Letrazole) and opted instead for Fenbendazole, DIM and Berberine together with a probiotic. My cancer is gone. The reproduction of cancer cells is destroyed by the Fenbendazole. I have not experience any side effects other than the metallic taste in my mouth which is the same one I had during chemo. I feel healthy and alive, my energy levels are returning, my state of mind is positive and for me cancer is a thing of the past.

  4. I wish they would tell you how much to take and how long to take it as a preventative. So far I see 222 mg every day but that seems like a lot for me as a preventative. I only weigh 110 lbs so am looking into it but it’s expensive to take every day. I’m wondering if twice a week would work? Or a smaller daily dosage? I’m not interested in spending $100 a month.

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