Grocery shopping

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In a nutshell

  • More than 15,000 synthetic food contact chemicals (FCCs) are in circulation—some at levels far higher than pesticides.
  • Ultra-processed foods (UPFs) expose consumers to multiple harmful substances, including BPA, phthalates, and PFAS.
  • Experts call for urgent regulatory reform, better safety testing, and less reliance on disposable packaging.

ZURICH, Switzerland — You might be watching calories or trying to avoid junk food, but there’s a bigger threat lurking in your kitchen. Beyond nutrition labels, a cocktail of synthetic chemicals has infiltrated the modern food supply. From farm to table, these substances accumulate in our bodies, potentially triggering serious health problems that doctors are only beginning to understand.

These contaminants come from various sources—packaging, processing equipment, storage containers—pathways most shoppers never consider.

A troubling new review published in Nature Medicine exposes how our food system has become a delivery vehicle for thousands of potentially harmful synthetic chemicals. The research team, led by Jane Muncke from the Food Packaging Forum Foundation, connects widespread chemical exposures to rising rates of chronic diseases including obesity, diabetes, and cancer.

What’s most concerning? The convenient, packaged foods that dominate grocery store shelves are among the worst offenders.

That microwave container holding your leftovers? There’s a strong chance that it contains bisphenol A (BPA), which disrupts hormone function. When heated, chemicals migrate more easily into food. Similarly, that bag of chips might expose you to “forever chemicals” known as PFAS that never break down in your body.

An infographic showing different things that contain PFAS
“Forever chemicals” can be found in common household products. (Francesco Scatena/Shutterstock)

Beyond Pesticides: The Real Chemical Culprits

While public attention has long focused on pesticide residues, the researchers emphasize that less scrutiny is paid to substances from packaging and processing. These “food contact chemicals” (FCCs) may actually pose a greater risk.

The numbers are striking: roughly 1,500 pesticides are in use globally, but more than 15,000 FCCs have been identified—and researchers estimate the true number could approach 100,000. Unlike pesticides, which typically appear at parts-per-billion levels (think a drop in an Olympic swimming pool), FCCs can be found in much higher concentrations—parts per million.

Most concerning is the inadequacy of current safety testing. Chemical assessments often examine substances individually, ignoring the real-world exposure to mixtures. Most evaluations focus on cancer risk, even though many FCCs—like endocrine disruptors—can cause harm at extremely low doses.

BPA illustrates this problem. Used in food packaging since the 1960s, its hormone-disrupting effects were first documented in the 1990s. Despite a recent European Union ban on BPA in food contact materials, the researchers note that the “enforcement threshold for the presence of BPA in foodstuffs is 1,000 times higher than the newly established tolerable daily intake,” due to the fact that “contemporary analytical chemistry methods are insufficient for measuring BPA in the ng-per-kg foodstuff range.” In short, even with new limits, the technology doesn’t yet allow for reliable enforcement.

Ultra-Processed Foods: A Chemical Cocktail

Ultra-processed foods (UPFs) represent a perfect storm of exposure. These products—which account for over 50% of daily calories in countries like the United States—undergo multiple processing steps, contact various materials, contain numerous additives, and often remain stored in packaging for extended periods, maximizing chemical migration.

The review notes that “studies from the USA have shown that greater higher consumption of UPFs, as well as dining out, are both associated with elevated levels of FCCs measured in people and in food.”

And the costs go beyond health. In the United States alone, diseases linked to plastic-related chemicals were estimated to cost society around $249 billion in 2018—roughly equivalent to Ecuador’s annual economic output.

“The evidence is becoming more and more clear that today’s packaged ultra-processed foods are convenient and hyperpalatable, but they contain many synthetic chemicals and microplastics from various sources,” Muncke says in a statement.

Junk food
Ultra-processed foods alone are bad enough. Combine them with toxic packaging and you’ve got a perform storm for poorer health. (Photo by Tim Samuel from Pexels)

What Can We Do About It?

Addressing this issue demands action at multiple levels. The authors call for tighter chemical regulations that ban hazardous substances, improve testing protocols for chemical mixtures, and promote safer packaging alternatives. They also recommend shifting food business models away from disposable plastics toward reusable materials like glass or stainless steel.

“We see that the health impacts of this type of food contamination are currently underappreciated and understudied. The scientific evidence shows a need for adopting a holistic approach to policymaking, that integrates considerations of planetary and human health, including hazardous FCCs and their impacts on health,” says Muncke. “All food packaging, processing equipment, and other food contact materials need to be adequately tested for their safety with regard to migrating food contact chemicals and microplastics using modern testing methods. New approaches to test for microplastics migration also need to be developed.”

For consumers, reducing reliance on ultra-processed foods remains one of the most effective ways to lower exposure. However, the researchers stress that “conscious consumption…cannot entirely reduce human exposure to FCCs and other synthetic food contaminants.” Even carefully planned dietary changes often fall short without broader regulatory reform.

As the researchers conclude, today’s food system prioritizes convenience and profit over health. Until regulation catches up with science, each meal may carry more than just calories—it could bring a dose of potentially harmful chemicals to your plate.

Paper Summary

Methodology

This paper is a comprehensive review article that examines the current scientific understanding of synthetic chemicals in food, with a focus on food contact chemicals (FCCs). The authors synthesized evidence from peer-reviewed studies, regulatory documents, and databases to identify the types, sources, and health impacts of synthetic chemicals in food. They specifically emphasized the connection between ultra-processed foods (UPFs) and chemical exposure, drawing on epidemiological studies like the NutriNet-Santé cohort that includes 180,000 people. The researchers analyzed migration pathways of chemicals from packaging and processing equipment into food, evaluated regulatory shortcomings in chemical safety assessment, and estimated the economic costs of health impacts associated with these exposures.

Results

The review found that humans are widely exposed to synthetic chemicals through food, with over 15,000 known FCCs and potentially up to 100,000 in existence. These chemicals migrate into food from packaging, processing equipment, and other food contact materials, with factors like heating, storage time, and food properties affecting migration rates. Ultra-processed foods were identified as particularly concerning sources of chemical exposure due to multiple processing steps and lengthy packaging contact. The authors documented associations between UPF consumption and numerous health conditions, including cancer, cardiovascular disease, type 2 diabetes, and obesity. They also found that specific FCCs like bisphenol A, phthalates, and PFAS have been linked to health effects including developmental impacts, obesity, and reproductive disorders. The economic costs of exposure to plastic-associated chemicals were estimated at $249 billion annually in the US alone.

Limitations

The authors acknowledge that while associations between UPF consumption and adverse health outcomes have been established, more research is needed to confirm the specific contribution of FCCs to these outcomes. They note challenges in studying chemical mixtures rather than individual substances, difficulties in measuring very low concentrations of some hazardous chemicals, and the lack of adequate toxicological testing for many FCCs. The review also points out that it’s difficult to completely eliminate exposure to these chemicals through individual dietary choices alone, as demonstrated by the limited success of dietary intervention studies.

Funding and Disclosures

The paper states that Jane Muncke is a full-time employee of the charitable, independent Food Packaging Forum Foundation. Author Mathilde Touvier was supported by the Agence Nationale de la Recherche under France 2030. Leonardo Trasande received support from multiple National Institutes of Health grants. Martin Scheringer received no specific funding for working on this review. The authors declared no competing interests.

Publication Information

This review article titled “Health impacts of exposure to synthetic chemicals in food” was authored by Jane Muncke, Mathilde Touvier, Leonardo Trasande, and Martin Scheringer. It was received by Nature Medicine on February 7, 2025, accepted on April 4, 2025, and published online in 2025 (specific publication date not provided in the materials). The article’s DOI is https://doi.org/10.1038/s41591-025-03697-5.

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