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In a nutshell
- Highly educated night owls showed significant cognitive decline over 10 years, while those with less education were unaffected regardless of sleep preferences
- The problem stems from rigid work schedules forcing night owls into chronic “social jetlag,” creating constant conflict with their natural sleep rhythms
- Poor sleep quality and smoking habits explained about 25% of the brain fog connection, suggesting targeted interventions could help
GRONINGEN, Netherlands — Your natural sleep schedule might be quietly damaging your brain, but only if you fall into a specific category of people. A decade-long study of nearly 24,000 adults has uncovered a troubling connection between being a night owl and cognitive decline — with a surprising twist.
The Education Factor Changes Everything
Researchers from the University of Groningen followed participants for 10 years and discovered that night owls experienced significantly more cognitive decline than early birds. That aforementioned twist? People with less education showed no such pattern, regardless of their sleep preferences.
Among college-educated participants, each hour shift toward being a night owl was associated with a 0.80-point decline in cognitive test scores over the decade. For someone with the most extreme late sleep schedule compared to an early riser, this translates to measurable differences in mental sharpness.
Your chronotype is simply your body’s natural preference for when to sleep and wake up. It’s controlled by your circadian rhythm, that internal 24-hour clock that regulates everything from body temperature to hormone production. About 20% of adults naturally prefer late bedtimes during midlife, while only 7% are extreme early birds.

Why Smart Night Owls Suffer More
The education connection appears to be about job flexibility. Highly educated people typically work rigid 9-to-5 office jobs. Executives, managers, teachers, and other professionals with strict morning schedules have little room for natural sleep preferences.
Meanwhile, people with less formal education often have more varied work schedules. Construction workers might start early, bartenders work nights, and service workers frequently have shifting schedules that could better match their natural sleep timing.
When your job forces you to wake up much earlier than your body wants, you experience what researchers call “social jet lag” — essentially chronic biological jet lag. Highly educated night owls may experience this more intensely because they have less control over their work schedules, constantly battling their natural rhythms.
“Children are morning people. That changes when you reach puberty, when you become an evening person,” says lead author Ana Wenzler in a statement. “Around your 20s, that gradually shifts back towards morning people for most people. By the age of 40, most people are morning people again. But this is certainly not the case for everyone. In this way, evening people deviate from the norm.”
Sleep Quality and Smoking Explain the Damage
The study, published in The Journal of Prevention of Alzheimer’s Disease, identified two key factors behind the cognitive decline: poor sleep quality and smoking habits. Among highly educated participants, these factors accounted for about one-third of the connection between being a night owl and brain fog.
Night owls reported worse sleep quality, which makes sense. If your body wants to stay up until 2 a.m. but you must wake at 6 a.m. for work, you’re chronically sleep-deprived. Poor sleep hampers the brain’s ability to clear waste products, including proteins associated with Alzheimer’s disease.
Smoking played a surprisingly large role, explaining about 19% of the cognitive decline. Night owls were more likely to smoke, possibly because nicotine provides short-term mental sharpness that helps them cope with the mismatch between their biological clock and work demands.
Alcohol consumption and physical activity levels didn’t explain the cognitive decline, even though night owls showed different patterns in these areas.
Sleep Quiz
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What This Means for Millions of Americans
About one in five American adults naturally prefer late sleep schedules, meaning millions could be affected, particularly those in professional careers demanding early starts. The study measured cognitive decline using tests of executive function and problem-solving skills that are important for planning and adapting to new situations.
While researchers can’t definitively say this decline leads to dementia, any measurable drop in cognitive function over a decade raises concerns. However, understanding these mechanisms could lead to solutions.
Flexible work schedules might particularly benefit highly educated night owls. Companies allowing later start times for employees whose biology favors evening hours could actually protect their workers’ long-term brain health.
Targeted sleep improvement and smoking cessation programs for night owls in demanding careers could also help. Since sleep quality and smoking explained 25% of the cognitive decline, addressing these factors could make a real difference.
We’ve published numerous studies on just how important sleep is when it comes to your body’s ability to function optimally. Natural sleep preferences might have real consequences for brain health, depending on how well your lifestyle fits your biological clock. If you’re a highly educated night owl stuck in an early-bird work world, you might be paying a cognitive price that builds up over decades. The solution isn’t forcing yourself to become a morning person, but finding ways to work with your natural rhythms or reduce the harm from constantly fighting them.
Paper Summary
Methodology
Researchers analyzed data from 23,798 adults aged 40 and older from the Lifelines cohort study in the Netherlands over approximately 10 years. Participants completed the Munich ChronoType Questionnaire to determine their natural sleep-wake preferences and took the Ruff Figural Fluency Test to measure cognitive function at the beginning and end of the study. The researchers used statistical methods to examine relationships between chronotype and cognitive decline, testing whether factors like education, sleep quality, alcohol intake, physical activity, and smoking explained any connections they found.
Results
Among highly educated participants, each one-hour shift toward being a night owl was associated with a 0.80-point decline in cognitive test scores over 10 years. No associations were found in low or middle education groups. Poor sleep quality mediated 13.5% of this association, while current smoking explained 18.6%. The combined effect of all measured factors accounted for about 25% of the total relationship between chronotype and cognitive decline in the highly educated group.
Limitations
The study only measured cognitive function twice over the decade, and focused specifically on executive function rather than other cognitive domains like memory. Participants who dropped out of the study had lower baseline cognitive scores, potentially affecting results. The cognitive tests were administered at different times of day without recording when, which could affect performance since night owls typically perform worse in morning hours. The study also couldn’t definitively separate the effects of chronotype itself from social jetlag.
Funding and Disclosures
This research was funded by the Dutch Medical Research Council (ZonMw) as part of the BIRD-NL consortium under the National Dementia Strategy 2021-2030. The authors declared no conflicts of interest. The Lifelines cohort study receives support from multiple Dutch government agencies and institutions.
Publication Information
Wenzler, A.N., Liefbroer, A.C., Oude Voshaar, R.C., & Smidt, N. “Chronotype as a potential risk factor for cognitive decline: The mediating role of sleep quality and health behaviours in a 10-year follow-up study.” The Journal of Prevention of Alzheimer’s Disease (2025). https://doi.org/10.1016/j.tjpad.2025.100168








The fairly recent discovery of the glymphatic system (the brain’s ability to detox harmful substances) appears to work only when in deep sleep.
Thus people who are sleep deprived will have a higher degree of toxic substances in the brain, and higher instances of neurodegenerative diseases like Alzheimer’, Parkinson’s and ALS
As one article stated “The glymphatic system is constantly filtering toxins from the brain, but during wakefulness, this system is mainly disengaged [1]”
The last few lines seem to contradict the headline and much if the article. Sounds like more rigid, controlled experiments are needed to make definitive conclusions.