
(Photo by Maude Frédérique Lavoie on Unsplash)
LITTLE ROCK, Ark. — It may be time to put beef back on the menu. As plant-based meat alternatives continue gaining popularity, many consumers wonder if these products provide the same nutritional benefits as traditional meat. A new study has some answers, finding that a regular beef burger stimulates muscle growth more effectively than the same amount of a soy-based meat alternative.
Researchers at the University of Arkansas for Medical Sciences (UAMS) compared how the body processes protein from traditional beef patties versus Impossible Burgers, one of the leading plant-based alternatives. The results suggest that while plant-based alternatives can eventually achieve similar muscle-building effects, you’d need to eat twice as much – and consume significantly more calories – to match the benefits of a single beef patty.
The study published in The American Journal of Clinical Nutrition involved 24 healthy adults between ages 18 and 40, randomly divided into three groups. One group ate a 4-ounce beef patty (similar to a quarter-pound burger), another consumed a 4-ounce Impossible Burger, and the third group ate two 4-ounce Impossible Burgers. Using sophisticated tracking methods involving stable isotopes – special molecules that can be traced through the body – researchers measured how efficiently each type of burger stimulated muscle protein synthesis, the process by which the body builds and repairs muscle tissue.
The results were clear: the single beef patty triggered significantly more muscle protein synthesis than the same size plant-based patty. While eating two Impossible Burgers (8 ounces total) eventually achieved similar muscle-building effects as the single beef burger, this required consuming nearly twice the calories (462 vs. 279 calories).
“While both beef and soy are considered ‘complete’ proteins, the amino acids in beef are simply more available for the muscle to use efficiently,” says Robert Wolfe, Ph.D., a UAMS professor of geriatrics and the study’s principal investigator, in a media release. “This efficiency can be important since the body is in a constant state of protein turnover to rebuild and repair proteins for functional health, especially when combined with physical activity and as part of healthy development and aging.”

What makes beef more effective?
The answer lies in how our bodies process different types of protein. Beef contains a higher concentration of essential amino acids – the building blocks of protein that our bodies can’t produce on their own. More importantly, these amino acids from beef appear in our bloodstream more quickly and in higher concentrations than those from soy-based alternatives.
Think of it like two different delivery services bringing supplies (amino acids) to a construction site (your muscles). The beef protein is like a direct express delivery that arrives quickly and all at once, giving the construction crew (your muscle-building machinery) everything they need to work efficiently. The soy protein is more like a slower delivery service that gets held up along the way, with some supplies being diverted to other locations before reaching the construction site.
This study doesn’t suggest that plant-based alternatives are nutritionally inadequate – they still provide protein and can stimulate muscle growth. However, consumers should understand that they may need to eat larger portions to achieve the same muscle-building benefits as meat, which means consuming more calories in the process.
“Protein quality matters as much as quantity,” Wolfe says. “This research underscores the fact that foods like nutrient-rich ground beef can offer more muscle-building benefits, and that’s critical as people make dietary choices, especially when balancing calorie intake.”
Paper Summary
Methodology
The researchers used a sophisticated approach called stable isotope tracer methods to track how the body processed proteins from each type of burger. Participants arrived at the clinic after fasting overnight and received careful monitoring for 10 hours. Special tagged amino acids were infused into their bloodstream, allowing researchers to track protein metabolism.
Blood samples were taken throughout the study, and small muscle tissue samples were collected at specific times to measure muscle protein synthesis rates. This methodology is considered the gold standard for measuring how the body processes dietary protein.
Key Results
The beef patty increased muscle protein synthesis by about 0.020 percentage points per hour above baseline levels, while the same size plant-based patty only increased it by 0.003 percentage points. Two plant-based patties achieved a 0.013 percentage point increase, closer to but not significantly different from the beef patty. The beef also led to quicker and higher peaks in blood amino acid levels, suggesting more efficient protein delivery to muscles.
Study Limitations
The study had several limitations. It only included younger adults (ages 18-40), so the results might differ in older populations. The macronutrient contents weren’t exactly matched between the beef and plant-based options, though this reflects real-world consumption patterns. The study also only measured effects after overnight fasting, so the results might vary in people who have eaten other meals throughout the day.
Discussion & Takeaways
The findings challenge some assumptions about protein equivalency in plant-based alternatives. While these products can provide adequate protein, they may require larger portions to match meat’s muscle-building effects. This has implications for both athletes focused on muscle development and older adults trying to maintain muscle mass. The study also suggests that the speed and concentration of amino acids reaching the bloodstream may be more important than just the total protein content listed on a nutrition label.
Funding & Disclosures
The study was financially supported by the National Cattlemen’s Beef Association, though the sponsor had no role in the study’s design, execution, interpretation, or writing. Several researchers disclosed receiving research grants from the National Cattlemen’s Beef Association, and one researcher owns a company that holds patents on amino acid-based nutritional supplements.
The lead author has performed freelance work for Soy Connection, funded by the United States Soy and United Soybean Board. These relationships were properly disclosed, and the findings were presented without manipulation.








These are not “new” findings. We’ve known this for decades.