Rapamycin, drug typically used in cancer therapy, emerges as powerful anti-aging remedy

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Scientists say medication also used after undergoing an organ transplant is capable of extending life with only brief use

COLOGNE, Germany — A drug that patients normally take during cancer therapy may have the power to increase the human lifespan, a new study reveals. Researchers in Germany say rapamycin can cause side-effects when patients take it as a lifelong anti-aging treatment. However, their new report finds even brief usage can have a dramatic impact on longevity while cutting down on side-effects.

Rapamycin is a cell growth inhibitor and immunosuppressant that people normally take while undergoing cancer treatment or after receiving an organ transplant. A team from the Max Planck Institute for Biology of Ageing, however, notes that the drug is also a promising anti-aging formula. Studies involving animals have found that low doses of rapamycin can extend life by preventing age-related changes in the intestines. Until now, however, scientists have looked at this drug as something patients would need to take for the rest of their lives.

READ: Taurine supplements could be the key to reversing the aging process

“At the doses used clinically, rapamycin can have undesirable side-effects, but for the use of the drug in the prevention of age-related decline, these need to be absent or minimal. Therefore, we wanted to find out when and how long we need to give rapamycin in order to achieve the same effects as lifelong treatment,” explains study lead investigator Dr. Paula Juricic in a university release.

Rapamycin treatment most effective when taken earlier in life?

The new study tested rapamycin in two short-term experiments using fruit flies and lab mice. The first treated young, adult flies for two weeks. The second treated young, adult mice (3 months-old) for a three-month period. In both experiments, the team found that rapamycin had a beneficial effect on the health of each animal’s intestines during middle age.

“These brief drug treatments in early adulthood produced just as strong protection as continuous treatment started at the same time. We also found that the rapamycin treatment had the strongest and best effects when given in early life as compared to middle age. When the flies were treated with rapamycin in late life, on the other hand, it had no effects at all. So, the rapamycin memory is activated primarily in early adulthood,” explains Dr. Thomas Leech, co-author of the paper.

“We have found a way to circumvent the need for chronic, long-term rapamycin intake, so it could be more practical to apply in humans,” adds co-author Dr. Yu-Xuan Lu.

READ: ‘Fountain of youth’ pill shows ability to dramatically increase longevity in mice

“It will be important to discover whether it is possible to achieve the geroprotective effects of rapamycin in mice and in humans with treatment starting later in life, since ideally the period of treatment should be minimized. It may be possible also to use intermittent dosing. This study has opened new doors, but also raised many new questions,” concludes senior author Prof. Linda Partridge.

More research is needed to confirm the results of the study while proving that rapamycin can be safely used as an anti-aging drug.

The study is published in the journal Nature Aging.

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Comments

  1. Were these studies done on “American” labrats & fruitflies..or an other nationality?? Cuz, there is a difference. America generally ages at much earlier stage! 😫

  2. Even more amazing is the discovery of Rapamycin. Named after the Rapanui of Easter Island and discovered in the soil there. I think there should be more to the story. It has been used for years to help regenerate new tissue and shouldn’t be ridiculously use for anyone’s political agenda.

  3. I found the article way behind what we know on Rapamycin. I have been taking intermittent doses of it for 4.5 years, no side effects other than it eliminated my gout and reduced my arthritis by about 60%. It also in a study has shown it improves the immune systems response to flu vaccines….wonder why older people die of the flu and vaccines have limited benefit? As we age our immune system slows down dramatically, so taking this makes any vaccine you get (flu, CV19, pneumonia, shingles) much more effective. No way to know if it will let me live alot longer, but it does have a good effect on inflamaging problems faced as we age. NO, its not over the counter, go see Dr. Alan Green look him up on http://www.rapamycintherapy.com. Alot to learn!

    1. Treat yourself good for a change. It’s time. To all. And while at, just go ahead and cut all emotionally negative ties that bind up the mind, heart and soul..and fresh start anew! Get back to basics, like it was intended to be, by appreciating even the smallest of things and celebrating every single tiny victory. After all, a Grateful Heart IS A Magnet For Miracles! And the proof is wherever you want to see it. 😉

      Be good to you, promise yourself you will drink enough spring* water to replace what your body uses up daily for respiration etc. (1.5 – 3.5L) If we don’t replace it every day a week, a year, a decade– then we’ve caused ourselves some serious issues.
      NoMore!
      Regenerate, revive, rejuvenate! Because you have to take care of you, so you’re ready when the time comes to do what you were called to do! So from the molecular level on up, healing the right way… Promise promise self you will allow your barefoot soles to touch the earth for at least 20mins a day… which is the secret quantum leap fast track to better health. That along with a bit of early & or lateday sunlight. You’ll be feeling brand new in no time! Well, 6 months to be exact. But brand new will feel brand new at 3months too!!!
      You just have to promise yourself, and don’t let yourself down this time cause were playing for keeps. Do not take a flu vaccine, or any vaccine. And instead trust the miracle workers – the magnetic Sun, magnetic Earth, magnetic water…
      Let them heal you and prove to you like they can.
      The more severe a health condition the more grounding/earthing is needed and the more spring or structured water is need.
      It’s all free, all it takes is trust & to do the “no big deal “things.
      God wants everyone to come to him, but if they are offered a wonderful life and keep throwing it all away, then he’s not going to keep trying after them. Especially if they won’t even follow a simple recipe for a guaranteed physical and mental health miracle! Anyone can do it and it works, guaranteed.

      We’ve got to mitigate the free radical accumulation, which is caused by molecular oxidative stress – which is what molecular inflammation is, besides the caues of most all disorder and disease.

      Ultimately there’s only 2 states.
      Stable and or unstable.
      So how would solve an unstable problem? Get to the root and stabilize.
      Everything that is unstable will create more areas that are unstable.
      Problem on the surface means the real problem is underneath, it’s not a stable operating system so it needs to be calibrated, like we used to be!

      Grounded and stable yet?
      Well get busybusy! 😉
      💫💛💫

  4. We (humans) are breeding ourselves into extinction at an accelerated rate and the last thing we need is longer life spans to cause more damage. The quicker we age and die, the better for the planet, the environment and the other creatures we share this planet with.

  5. Who wants to live forever??? Not me that’s for certain, I would however LOVE to have Kris Kardashians plastic surgeon! Now that would be just FANTASTIC especially if it were totally free like uh maybe a 66th birthday gift? Whatcha say Powers That Be??? Lemme know k? Thanks

  6. I call bullshit. No way a cell growth inhibitor/immunosuppressant is going to drastically increase lifespan. I have my doubts it could even slightly increased lifespan. The intestinal benefits are nearly irrelevant, welcome to a single component of the aging process out of an infinite number of variables. Let me know when we see a significantly lengthened telomeres or cancellation of free radicals. We’re not on the brink of immortality, we aren’t even close. Not even the bourgeoisie will see immortality in this lifetime, and God willing humanity will wipe itself out before it’s even a possibility.

    1. Have you seen the research papers on telomeres and hyperbaric chambers that came out of the University of Tel Aviv earlier this year?

      No one wants to live forever on earth, but living longer, healthier, adn more youthfully? Sign me up.

  7. You will not be allowed to have it since governments need you to die sooner rather than live longer. Now take you 15th mRNA booster and wait for the results.

    1. Take your 15th dose of horse tranquilizer, wake up and see if you’re still a one of trump’s dullard little ass-slaves in the morning, “Ass-To-Mouth”. Get sterilized.

      1. Ivermectin isn’t a horse tranquilizer. Billions of safe uses in humans. You might want to read up on the current problems associated with the Phizer and Moderna immunotherapies. I can’t in good conscience call them a vaxx because they are anything but.

        1. Richard small…name matches the 1984 brainwashing of the masses mentality….see India….the whole pop given th ” horse tranquilizer” whrre are the millIon dead peep in the slums?
          And ..ohh..natyral chloroquine..boom..no deaths…
          This dude prolky still masking up..and 6 feet of seperation…both proven hoaxes…prolly buys the hoax globalists climate change..and green hoax energy..the ethynol n windmill hoaxes…the not let #1 tennis player in the world into the usa but let millions if unvaxed military and gangs in..the border hoax

          1. It seems you do not know a hoax from a hound dog. Apparently you were never trained to think, but just react by rote -something Fox News depends upon. Sort of like airline pilots and Fox News commentators -self-important and overpaid, but never missed for long if disappearance is noted at all.

      2. Hey Richard!
        I’ll bet you are one of the haters who took the ‘lethal injection’! Explain why you don’t think you’re an ‘Ass-To-Mouth” “dullard little (again) ass slave” because it seems you’re projecting… How’s that jab incubating? Got your clots yet? I am just fascinated with all these cancers, heart attacks strokes, auto immune disorders, and especially the ‘died suddenly’s’. Oh well,,, we’ll have to keep our eyes on YOU! We may be on a ’15th dose of horse tranquilizer” but we’re sure not dropping like you libtards are after your 3rd, 4th, or 5th, booster. Oh well, See ya around Sucker – oh wait, probably not.

        1. The lethal injection that billions took and are fine from. You Trumper loons really lost all sense of reality lmao

      3. Hey Hater!

        It’s not a tranquilizer but …. since you’re so genius
        how about YOU take your next Booster then tell us who the ‘dullard little ass-slaves’ really are.
        Enjoy your blood clots!

      4. You poor thing. Trump lives in your deranged little mind 27/7, even though he is no longer in office and has zero efect on your miserable little life.

        Have you considered therapy?

  8. “Rapamycin”. Rap-a-mycin. Would learning to rap and making use of beneficial fungi be a good use of ones time in the mean time? In the direction of keeping one young and vital that is.
    I’ll be waiting on Ab-Fabimycin too.
    Maybe I’ll take them both, be here another 100 years bothering you.

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